Ezetimibe

Fungal biotransformation of ezetimibe

Structural transformation of ezetimibe was performed by fungi Beauvaria bassiana and Cunninghamella blakesleeana. The metabolites were identified by different spectroscopic techniques as (3R,4S)-1-(4-fluorophenyl)-3-((E)-3-(4-fluorophenyl) allyl)-4-(4-hydroxyphenyl) azetidin-2-one (2), (3R, 4S)-1-(4-fluorophenyl)-3-(3-(4fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl) azetidin-2-one (3), (3R,4S) ...

Zetia (ezetimibe) Tablets

Ezetimibe is a white, crystalline powder that is freely to very soluble in ethanol, methanol, and acetone and practically insoluble in water. Ezetimibe has a melting point of about 163°C and is stable at ambient temperature. ZETIA is available as a tablet for oral administration containing 10 mg of ezetimibe and the following inactive ingredients: croscarmellose sodium NF, lactose monohydrate N...

Does ezetimibe modify clinical outcomes?

Extract from the Clinical Evaluation Report for ezetimibe and ezetimibe / simvastatin

Ezetimibe coadministered with fenofibrate: some safety questions.

Ezetimibe coadministered with fenofibrate: some safety questions I would like to comment on some questions in reference to the article of Dr Farnier and co-workers on the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidemia. 1 First, criteria of clinical and/or laboratory muscle-related adverse events are not referenced and are not in accordance with the recently...